Levomefolate calcium CAS 151533-22-1

Key Features

✅ Premium Bioactive Folate – Highly bioavailable calcium salt form of L-5-MTHF
✅ MTHFR Mutation-Friendly – Bypasses enzymatic conversion issues
✅ Pharmaceutical Grade – Manufactured under strict cGMP compliance
✅ Superior Stability – Enhanced shelf life vs. free acid form
✅ Versatile Applications – Suitable for pharmaceuticals, nutraceuticals, and clinical research

Batch-specific CoA available on request.

Levomefolate Calcium (also known as Calcium (6S)-5-methyltetrahydrofolate) is the pharmaceutical-grade calcium salt of the biologically active folate form. This compound offers:
✔ Better absorption than folic acid, ideal for individuals with MTHFR mutations
✔ Higher stability in formulations (tablets, capsules, powders)
✔ Proven efficacy in treating depression, cardiovascular risks, and prenatal deficiencies

1. Product Identification

Parameter	Specification
IUPAC Name	Calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
Common Names	L-Methylfolate Calcium; (6S)-5-MTHF Ca Salt
CAS Number	151533-22-1
Molecular Formula	C₂₀H₂₃CaN₇O₆
Molecular Weight	497.53 g/mol
EC Number	–
Appearance	Yellow-orange crystalline powder

2. Quality Specifications (Pharmaceutical Grade)

Test Parameter	Specification	Method
Purity (HPLC)	≥97.0%	USP <621>
Water Content	≤6.0%	Karl Fischer
Optical Rotation	+14° to +18° (c=1 in 0.1M NaOH)	Polarimetry
Heavy Metals	≤10 ppm	ICP-MS
Related Substances	Total impurities ≤2.0%	HPLC-UV
Residual Solvents	Meets ICH Q3C limits	GC-HS
Microbial Limits	Complies with EP 2.6.12	Microbial enumeration

3. Physicochemical Properties

Property	Value	Test Condition
Solubility	25 mg/mL in water (pH 6-7)	25°C
Melting Point	Decomposes at 210-215°C	DSC
pKa Values	3.1, 4.8, 10.2	Potentiometric
LogP (Octanol/Water)	-2.1 (predicted)	Computational
Hygroscopicity	Slightly hygroscopic	DVS Analysis
Photostability	Sensitive to light (store in amber vials)	ICH Q1B

4. Product Applications

✔ Pharmaceutical Uses

Depression & Cognitive Health (adjuvant with SSRIs)
Prenatal Supplements (reduces neural tube defects)
Cardiovascular Protection (lowers homocysteine levels)
MTHFR Gene Mutation Therapy (bypasses defective enzyme)

✔ Nutraceutical Formulations

High-Potency Folate Supplements (better absorption than folic acid)
Functional Foods & Beverages (stable in fortified products)
Gummies & Chewables (compatible with common excipients)

✔ Research & Development

Cell Culture Media Additive
Neurodegenerative Disease Studies
Epigenetic & Methylation Research

5. Packaging & Storage

Packaging Option	Description
1 g – 25 g	Amber glass vial, nitrogen-purged
50 g – 1 kg	Double HDPE bags, vacuum-sealed with desiccant
Bulk Quantities	Custom packaging (foil-lined drums, nitrogen-flushed)

Storage Conditions:

Recommended: -20°C (long-term), 2-8°C (short-term)
Humidity Control: ≤60% RH (desiccated)
Protection from Light: Store in amber vials or opaque containers

Shelf Life: 36 months when stored properly

6. Safety & Handling

Regulatory Compliance

✔ GRAS (Generally Recognized as Safe) for food use
✔ USP/EP/JP compliant
✔ DMF Available (US/EU/JP)

Safety Profile

GHS Classification: Non-hazardous
Precautionary Statements:
- P264: Wash hands thoroughly after handling
- P280: Wear gloves/eye protection
- P302+P352: If on skin, wash with soap/water

First Aid Measures

Skin Contact: Wash with soap & water
Eye Contact: Rinse with water for 15 minutes
Ingestion: Seek medical attention if large amounts are ingested

Disposal

Incineration at controlled facilities
Follow local environmental regulations

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

Custom Synthesis Service

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VIP Customer Service

Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.