Pharmaceutical Standard Folinic Acid Calcium CAS 1492-18-8 USP/EP/BP/CP

Key Features

✔ High-purity (>98%) calcium folinate for critical applications
✔ GMP-compliant manufacturing with full traceability
✔ Dual pharmaceutical and research applications
✔ Enhanced stability profile with 36-month shelf life
✔ Available in customized formulations

Batch-specific CoA available on request.

1. Product Description

High-purity folinic acid calcium salt (>98%) for pharmaceutical manufacturing and clinical research. Serves as:
✓ Active Pharmaceutical Ingredient (API) in antidote formulations
✓ Biochemical reagent for cell culture studies
✓ Key intermediate in folate metabolism research

Compliance: Meets EP/USP/ChP standards, manufactured under cGMP.

2. Product Identification

Parameter	Specification
Chemical Name	Calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-5,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
Synonyms	Leucovorin calcium, 5-Formyltetrahydrofolate calcium
CAS No.	1492-18-8
Molecular Formula	C₂₀H₂₁CaN₇O₇
Molecular Weight	511.50 g/mol

3. Quality Specifications

Appearance: Off-white to light yellow crystalline powder
Purity (HPLC): ≥98.0%
Water Content (KF): ≤8.0%
Impurities:

Single unknown impurity ≤0.5%
Total impurities ≤2.0%
Identification:
IR spectrum matches reference standard
Positive calcium ion test

4. Physicochemical Properties

Property	Value
Solubility	50 mg/mL in water (25°C)
pH (1% sol.)	6.0–8.0
Optical Rotation	+15° to +20° (c=1, 0.1N NaOH)
Melting Point	Decomposes at ~240°C

5. Applications

Therapeutic Uses:

Reduces toxicity in methotrexate therapy
Enhances 5-FU chemotherapy efficacy
Treatment for folate deficiency anemia

Research Applications:

Cell culture media supplement
Enzyme inhibition studies
Isotope-labeled compound synthesis

6. Packaging & Storage

Standard Packaging:

1 kg aluminum foil bags with desiccant
5 kg HDPE bottles
Custom bulk packaging available

Storage Conditions:

Temperature: 2–8°C (refrigerated)
Humidity: ≤65% RH
Light Sensitivity: Protect from light
Shelf Life: 36 months unopened

7. Safety & Handling

GHS Classification: Non-hazardous
Precautions:

Avoid dust generation (use local exhaust)
Wear nitrile gloves and safety goggles
First Aid:
Eye contact: Rinse ≥15 minutes with water
Ingestion: Seek medical attention

8. Regulatory & Documentation

✔ Batch-specific Certificate of Analysis
✔ Available EDMF/ASMF/DMF filings
✔ GMP compliance documentation
✔ SDS upon request

9. Ordering Information

Product Code: FA-CA-98
MOQ: 100 g
Lead Time: 2–3 weeks
Customization:

Particle size adjustment
Sterile filtration available

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

Custom Synthesis Service

Certified Quality Control

Shipping Order Track

Strict Confidentiality

VIP Customer Service

Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.