D-Cysteine hydrochloride CAS 32443-99-5

Key Features

✔ Chiral Cysteine Derivative: D-enantiomer with ≥99% optical purity
✔ Pharma-Grade Salt: Hydrochloride form enhances stability & solubility
✔ Reactive Thiol Group: Enables disulfide bonding & metal chelation
✔ Multi-Functional Applications: From radioprotectants to asymmetric synthesis
✔ Strict QC Standards: Complies with USP/EP testing protocols

Batch-specific CoA available on request.

1. Product Identification

IUPAC Name: (2R)-2-Amino-3-sulfanylpropanoic acid hydrochloride
CAS No.: 32443-99-5
Molecular Formula: C₃H₇NO₂S·HCl
Molecular Weight: 157.61 g/mol
Structural Verification:
- Optical Rotation: [α]²⁵D = +11.5° to +13.5° (c=1 in 1N HCl)
- FTIR (KBr): 2550 cm⁻¹ (S-H stretch), 1730 cm⁻¹ (C=O)
- LC-MS: m/z 122.01 [M+H-HCl]⁺

2. Quality Specifications (USP/EP Compliant)

Parameter	Specification	Test Method
Assay (titration)	98.0–101.0%	Non-aqueous titration
Optical purity	≥99.0% ee	Chiral HPLC
Water content	≤0.5% w/w	Karl Fischer
Residue on ignition	≤0.1%	USP <281>
Heavy metals (Pb)	≤10 ppm	ICP-MS
Sulfhydryl activity	≥98% of theoretical	Ellman’s reagent

3. Physicochemical Properties

Appearance: White crystalline powder
Melting Point: 178–182°C (dec.)
Solubility:
- Water: >500 mg/mL (clear, colorless solution at 25°C)
- Alcohol: Slightly soluble
- Organic Solvents: Insoluble in ether/hexane
pKa Values:
- COOH: 1.71 | NH₃⁺: 8.33 | SH: 10.36
LogP: -2.1 (pH 7.0)

4. Product Applications

Pharmaceutical Uses

Radiation Mitigation: Free radical scavenger in radioprotective drugs
Heavy Metal Antidotes: Preferred over L-form for Hg²⁺/Pb²⁺ chelation
Enzyme Inhibitors: Cysteine protease active-site modifier

Chemical Synthesis

Chiral Auxiliary: Asymmetric C–S bond formation
Surface Chemistry: Gold nanoparticle functionalization via Au–S bonds
Protecting Group Strategies: Orthogonal NH₂/SH protection possible

5. Packaging & Storage

Primary Packaging:
- ≤1 kg: Double-bagged aluminized pouches with desiccant
- Bulk: HDPE drums with nitrogen purge
Storage Conditions:
- Temperature: 2–8°C (long-term), ≤25°C (in-use)
- Humidity: ≤30% RH
- Light Protection: Required (amber glass/OPP bags)
Shelf Life: 3 years when stored properly

6. Safety & Handling

GHS Hazard Statements

H302: Harmful if swallowed
H315: Causes skin irritation
H317: May cause allergic skin reaction
H318: Causes serious eye damage

Safety Protocols

PPE Requirements: Nitrile gloves + chemical goggles + lab coat
Ventilation: Use fume hood for powder handling
Spill Management: Absorb with silica gel, neutralize with 1M NaOH

First Aid Measures

Skin Contact: Wash with 5% ascorbic acid solution
Eye Contact: Irrigate with sterile saline for ≥15 min
Ingestion: Administer activated charcoal slurry

Technical Support

Custom Services:
- N-Boc/Fmoc-protected derivatives
- Deuterated (D₇) variants for MS studies

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.