Calcium N5-methyltetrahydrofolate CAS 26560-38-3

Key Features

✔ Superior stability salt form
✔ Bioactive folate bypassing MTHFR polymorphism
✔ Manufactured under cGMP
✔ Multi-compendial compliance

Batch-specific CoA available on request.

PRODUCT DESCRIPTION

Calcium N5-methyltetrahydrofolate is the gold-standard bioactive folate form for pharmaceutical and nutraceutical applications. This thermostable calcium salt demonstrates:

98% oral bioavailability (vs. 60% for folic acid)
10× higher CSF penetration (critical for neurological applications)
pH-stable in formulations (3.0-8.5 range)

1. PRODUCT IDENTIFICATION

Parameter	Specification
IUPAC Name	Calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
CAS No.	26560-38-3
EC No.	247-779-8
Molecular Formula	C₂₀H₂₃CaN₇O₆
Molecular Weight	497.53 g/mol

2. QUALITY SPECIFICATIONS (Batch Release Criteria)

Test	Specification	Method
Appearance	Yellow-orange crystalline powder	Visual
Identification (HPLC)	Retention time matches reference standard	EP 10.0 Ch. 2.2.29
Assay (HPLC)	97.0-103.0% (anhydrous basis)	USP ⟨621⟩
Water Content	≤6.0% w/w	Karl Fischer
Optical Rotation	+14° to +18° (c=1 in 0.1M NaOH)	Polarimetry
Heavy Metals	≤10 ppm	ICP-OES
Related Substances	Total impurities ≤2.0%	HPLC-UV

3. PHYSICOCHEMICAL PROPERTIES

Property	Value	Test Condition
Solubility	27 mg/mL	Water, 25°C, pH 7.0
LogP	-2.1	Predicted (ACD/Labs)
pKa Values	3.1, 4.8, 10.2	Potentiometric titration
Melting Point	Decomposes at 210-215°C	DSC
Hygroscopicity	Slightly hygroscopic (≤0.5% Δw/w at 60% RH)	Dynamic Vapor Sorption

4. PRODUCT APPLICATIONS

Pharmaceutical Formulations:

Tablets/Capsules: 400 mcg to 15 mg dosing (direct compression compatible)
Injectables: Lyophilized powder for reconstitution (pH 8.0-8.5 recommended)

Clinical Indications:

Major depressive disorder (adjunct therapy)
Hyperhomocysteinemia management
Prenatal supplementation (superior placental transfer)

Excipient Compatibility Data:

Stable with MCC, lactose, croscarmellose sodium
Avoid strong oxidizers (ascorbic acid requires ≥5:1 ratio)

5. PACKAGING & STORAGE

Primary Packaging Options:

Size	Container	Headspace
≤50g	Amber glass vial with N₂ purge	≤5% O₂
100g-5kg	Double HDPE bag in foil drum	Oxygen absorber

Storage Conditions:

Long-term: -20±5°C (desiccated, ≤25% RH)
Transport: ≤25°C for ≤30 days with cold packs
Shelf Life: 36 months when stored properly

6. SAFETY & HANDLING

Hazard Classification: Non-hazardous (GHS compliant)

Precautionary Statements:

P264: Wash hands thoroughly after handling
P280: Wear protective gloves/eye protection
P302+P352: IF ON SKIN: Wash with plenty of water

First Aid Measures:

Inhalation: Move to fresh air
Eye Contact: Rinse with water for 15 minutes
Ingestion: Rinse mouth, seek medical attention

Disposal: Incinerate at >1000°C with exhaust gas treatment

TECHNICAL SUPPORT SERVICES

Method transfer protocols (HPLC/UPLC)
Forced degradation studies (ICH Q1A compliant)
Salt form optimization (glucosamine/magnesium alternatives)

Certificate of Analysis and Safety Data Sheet provided with every shipment.
Custom particle size distributions (10-150μm) available upon request.

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Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.