2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate CAS 122111-01-7

Key Features

✔High-purity fluorinated carbohydrate derivative (>98% HPLC)
✔Key intermediate for gemcitabine and related anticancer drugs
✔Dual benzoate protection enables selective deprotection
✔Strictly controlled residual solvents (<500 ppm)
✔Available from milligram to kilogram scale

Batch-specific CoA available on request.

Product Description

(R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate is a chiral fluorinated building block designed for:

Asymmetric synthesis of bioactive molecules
Introduction of metabolically stable difluoromethylene groups
Constructing enzyme inhibitors and protease-resistant peptidomimetics

Its acetal and ethyl ester protections enable orthogonal deprotection strategies in multistep syntheses.

1. Product Identification

Chemical Name: (R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate
CAS No: 95058-92-7
Molecular Formula: C₁₀H₁₆F₂O₅
Molecular Weight: 254.23 g/mol
EC Number: Not assigned
Synonyms: (R,R)-Difluoro-dioxolane hydroxypropanoate

2. Quality Specifications

Parameter	Specification	Test Method
Purity (HPLC)	≥98% (area%)	RP-HPLC (UV 210nm)
Diastereomeric Excess	≥98% de	Chiral HPLC
Water Content	≤0.5% (KF)	Karl Fischer
Residual Solvents	≤500 ppm (total)	GC-MS
Appearance	Colorless to pale yellow liquid	Visual inspection

3. Physicochemical Properties

Boiling Point: ~150°C (0.5 mmHg, decomp.)
Density: 1.25–1.30 g/cm³ (25°C)
Refractive Index: n²⁰D = 1.415–1.425
Solubility: Soluble in ethanol, THF, DCM; insoluble in water
Storage Stability: ≥12 months at –20°C (N₂ atmosphere)

4. Product Applications

Pharmaceutical Intermediates

Fluorinated drug candidates (e.g., protease/CDK inhibitors)
Stereo-defined β-hydroxy acid derivatives

Agrochemicals

Chiral fluorinated pesticide precursors

Academic Research

Probe molecules for enzyme mechanism studies

5. Packaging & Storage

Standard Packaging:
- 5g, 25g (amber glass vials, septa-sealed)
- 100g–5kg (HDPE drums with N₂ blanket)
Storage Conditions:
- –20°C, protected from light/moisture
- Inert atmosphere recommended

6. Safety & Handling

⚠ Hazard Statements:

H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation

🔹 Precautionary Measures:

Use gloves (nitrile) and safety goggles
Avoid inhalation – handle in fume hood
Store away from strong oxidizers

First Aid:

Skin contact: Wash with soap/water
Eye contact: Rinse with water (15 min), seek medical help
SPILL: Absorb with inert material (e.g., vermiculite)

Additional Notes

Bulk quantities (>1kg) include NMR/MS validation. Custom purity (≥99%) or derivatization services available upon request.

For TDS (Technical Data Sheet) or safety protocols, contact [email protected].

Would you like a synthetic use case highlighting this compound? Let us know!

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.