D-Cysteine HCl hydrate CAS 207121-46-8

Key Features

✔ Non-Natural Isomer: D-configuration for specialized biochemical applications
✔ High Optical Purity: ≥99% enantiomeric excess (ee) by chiral HPLC
✔ Stabilized Form: Hydrochloride hydrate enhances solubility & shelf stability
✔ GMP-grade Available: Qualified for pharmaceutical use (ISO 9001 certified)
✔ Multi-disciplinary Applications: From chelation therapy to asymmetric synthesis

Batch-specific CoA available on request.

Product Description

This chiral thiol amino acid derivative provides:

Controlled Stereochemistry: Strict D-configuration at α-carbon
Reactive Thiol Group: Enables disulfide bridge formation (–SH to –S–S–)
Enhanced Solubility: Hydrochloride salt form (typically monohydrate)

Key Advantages:
● Critical precursor for selenium-containing enzyme mimics
● Unique coordination properties for heavy metal chelation
● Orthogonal protection strategies available (–NH₂ vs. –SH)

1. Product Identification

IUPAC Name: (2R)-2-Amino-3-sulfanylpropanoic acid hydrochloride hydrate
CAS: 207121-46-8
Molecular Formula: C₃H₇NO₂S·HCl·xH₂O (x≈1)
MW (anhydrous): 157.61 g/mol
Structural Verification:
- [α]²⁵D = +12.5° ± 1° (c=2, 1N HCl)
- FTIR: Characteristic S–H stretch at 2550 cm⁻¹
- LC-MS: m/z 122 [M+H–HCl]⁺

2. Quality Specifications

Parameter	Specification	Test Method
Assay (dry basis)	98.0–101.0%	Non-aqueous titration
Optical purity	≥99% ee	Chiral CE (pH 2.5 buffer)
Sulfhydryl content	≥95% of theoretical	Ellman’s assay
Water content	5.0–12.0%	Karl Fischer
Heavy metals (Pb)	≤10 ppm	ICP-OES
Residual solvents	MeOH <3000 ppm	GC-FID

3. Physicochemical Properties

Melting Point: 175–180°C (dec.)
Solubility:
- Highly soluble: Water (>500 mg/mL)
- Sparingly soluble: Ethanol (<10 mg/mL)
- Insoluble: Ether, hexane
pKa Values:
- COOH: 1.92
  – NH₃⁺: 8.35
  – SH: 10.46
Oxidation Sensitivity: Forms cystine rapidly at pH >7

4. Product Applications

Biomedical Uses

Radiation Protection: Thiol group scavenges free radicals
Heavy Metal Detox: Chelates Hg²⁺/Cd²⁺ with higher affinity than L-isomer
Enzyme Inhibitors: Active site-directed probes for proteases

Chemical Synthesis

Chiral Building Block:
- Asymmetric synthesis of β-lactams
- Organocatalysts for Michael additions
Surface Modification:
- SAMs (self-assembled monolayers) on gold

5. Packaging & Storage

Primary Containers:
- ≤100g: Nitrogen-flushed amber glass vials
- Bulk: Poly-lined steel drums
Storage Conditions:
- Temperature: –20°C (long-term), RT for daily use
- Atmosphere: Argon overlay recommended
- Stability: 3 years when desiccated (<5% RH)

6. Safety & Handling

GHS Classification

H302: Harmful if swallowed
H315: Skin irritation
H317: May cause allergic skin reaction
H318: Causes serious eye damage

Handling Protocol

PPE: Butyl gloves + splash goggles
Work Environment: N₂-purged glovebox for large scale
Incompatibilities: Strong oxidizers, heavy metal salts

First Aid

Oral Exposure: Administer activated charcoal
Ocular: Irrigate with 0.9% saline for 15 min
Spill Control: Absorb with molecular sieves

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

Custom Synthesis Service

Certified Quality Control

Shipping Order Track

Strict Confidentiality

VIP Customer Service

Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.