4′-Demethylepipodophyllotoxin CAS 6559-91-7

Key Features

✔Podophyllotoxin Derivative: Core structure for semi-synthetic anticancer agents
✔High-Purity Intermediate: ≥98% (HPLC) for pharmaceutical synthesis
✔Multi-Drug Precursor: Key starting material for etoposide, teniposide, and tafluposide
✔Trans-Lactone Configuration: Optimal bioactivity conformation
✔Chirally Pure: Single stereoisomer (>99% ee by chiral HPLC)

Batch-specific CoA available on request.

Product Description

This natural product-derived compound serves as: ✔ Critical Intermediate for topoisomerase II inhibitors
✔ Structural Platform for novel prodrug development
✔ Biologically Active Core with direct cytotoxic effects

Structural Advantages:

Preserved tetracyclic ring system essential for DNA interaction
Free 4'-phenolic OH enables targeted modifications
Cis-fused lactone maintains required rigidity for binding

1. Product Identification

IUPAC Name: (5R,5aR,8aR)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
CAS Number: 6559-91-7
Molecular Formula: C₂₁H₂₀O₈
Molecular Weight: 400.38 g/mol
Structural Verification:
- UV λmax: 285 nm (ε=5000)
- [α]²⁵D: -147° ± 3° (c=1, CHCl₃)
- LC-MS: m/z 401.12 [M+H]⁺

2. Quality Specifications

Parameter	Specification	Test Method
Appearance	White to pale yellow powder	Visual
Purity (HPLC)	≥98.0%	RP-HPLC (220 nm)
Related Substances	≤1.0% total impurities	HPLC
Residual Solvents	≤0.5% total	GC
Heavy Metals	≤10 ppm	ICP-MS

3. Physicochemical Properties

Melting Point: 226-230°C (dec.)
Solubility:
- Freely soluble: DCM, DMSO
- Soluble: Acetone, methanol
- Practically insoluble: Water (<0.01 mg/mL)
LogP: 2.8 ± 0.2
Stability: Stable >3 years at 2-8°C (desiccated, amber glass)

4. Product Applications

Pharmaceutical Synthesis

Etoposide/Teniposide Production:
- Glycosylation precursor
- 4'-Phosphorylation intermediate
Novel Analog Development:
- C4 modifications for improved solubility
- Prodrug conjugation via phenolic OH

Research Uses

Topoisomerase Studies:
- Photoaffinity labeling probes
- Radioligand development
Apoptosis Research:
- Caspase activation studies

5. Packaging & Storage

Primary Packaging:
- ≤10g: Amber glass vials with nitrogen purge
- 10-100g: Al-foil bags with oxygen scavenger
Storage Conditions:
- Temperature: 2-8°C
- Humidity: ≤40% RH
- Light Protection: Essential
Shelf Life: 5 years under recommended conditions

6. Safety & Handling

GHS Classification

H301: Toxic if swallowed
H315: Skin irritation
H319: Eye irritation

Protective Measures

PPE: Gloves (nitrile), face protection
Engineering Controls: Fume hood recommended
Spill Management: Inert absorbent material

First Aid

Skin: Wash with PEG-400 solution
Eyes: 15 min water irrigation
Ingestion: Medical attention immediately

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.