Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate CAS 95058-92-7

(R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate

Key Features

✔ High chiral purity (≥98% de)
✔ Dual-protected fluorinated hydroxyester – ideal for selective reactivity
✔ Critical synthon for fluorinated drug candidates
✔ Scalable batch sizes (100g to 50kg+)
✔ Regulatory-compliant documentation (CoA, MSDS)

Batch-specific CoA available on request.

Product Description

(R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate is a chiral fluorinated synthon specifically designed for pharmaceutical applications. The compound features:

Stereodefined (R,R) configuration
Difluoromethylene group for metabolic stability
Orthogonal protecting groups (acid-stable dioxolane and base-stable ethyl ester)
Versatile reactivity for further functionalization

1. Product Identification

Chemical Name: (R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate
CAS Number: 95058-92-7
Molecular Formula: C₁₀H₁₆F₂O₅
Molecular Weight: 254.23 g/mol

2. Quality Specifications

Parameter	Specification	Test Method
Appearance	Colorless to pale yellow liquid	Visual
Purity (HPLC)	≥98.0%	RP-HPLC
Diastereomeric excess	≥98% de	Chiral HPLC
Water content	≤0.5% w/w	Karl Fischer
Residual solvents	Meets ICH Q3C limits	GC

3. Physicochemical Properties

Physical State: Liquid at room temperature
Density: 1.27 ± 0.03 g/cm³ at 20°C
Refractive Index: nD²⁰ = 1.420 ± 0.005
Solubility:
- Soluble in common organic solvents (DCM, THF, EtOH)
- Sparingly soluble in water (<0.1 g/100 mL)
Storage Stability: Stable for ≥12 months at -20°C under inert atmosphere

4. Product Applications

Key intermediate for proteasome inhibitors
Building block for fluorinated bioactive molecules:
- Antiviral agents
- Enzyme inhibitors
- Antibiotics
Chiral template for asymmetric synthesis
Material science applications (fluorinated polymers)

5. Packaging & Storage

Standard Packaging Options:
- Research quantities: 1g, 5g, 25g in amber glass vials
- Bulk quantities: 100g to 50kg in HDPE containers with N₂ overlay
Storage Conditions:
- Recommended: -20°C protected from light and moisture
- Short-term: 2-8°C for up to 1 month
- Always store under inert gas (Ar/N₂)
Shelf Life: 24 months when stored properly

6. Safety & Handling

GHS Classification:
- Skin Irritant (Category 2)
- Eye Irritant (Category 2A)
- Not classified as acutely toxic
PPE Requirements:
- Chemical-resistant gloves (nitrile recommended)
- Safety goggles or face shield
- Lab coat or protective clothing
First Aid Measures:
- Eye contact: Rinse immediately with water for 15 minutes
- Skin contact: Wash thoroughly with soap and water
- Inhalation: Move to fresh air immediately
- Ingestion: Rinse mouth and seek medical advice
Disposal: Dispose of according to local regulations for organic fluorinated compounds

Note: Full safety data sheet (SDS) available upon request. For large-scale orders (>1kg), we provide technical support for handling and process integration.

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.