(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde CAS 15186-48-8

Key Features

✔ High Chiral Purity – ≥98% ee (HPLC)
✔ Versatile Intermediate – Used in pharma, sugars, and antibiotics
✔ Stable Liquid Form – Easy to handle & measure
✔ Technical Grade – ≥98% purity (GC, low impurities)
✔ Controlled Packaging – N₂-sealed, light-protected vials
Batch-specific CoA available on request.

Batch-specific CoA available on request.

1. Product Identification

1.1 Chemical Data

Parameter	Specification
IUPAC Name	(R)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde
CAS Number	15186-48-8
Molecular Formula	C₆H₁₀O₃
Molecular Weight	130.14 g/mol
EC Number	239-223-5

1.2 Structural Characteristics

✓ Chirality: (R)-enantiomer (optical purity ≥98% ee)
✓ Functional Groups: Protected aldehyde (acetal form)

2. Quality Specifications

2.1 Visual & Physical Properties

Parameter	Specification	Method
Appearance	Colorless to pale yellow liquid	Visual
Odor	Characteristic aldehyde odor	Organoleptic

2.2 Chemical Purity

Parameter	Specification	Test Method
Purity (GC)	≥98.0%	Gas Chromatography
Optical Purity	≥98% ee	Chiral HPLC
Water Content	≤0.5%	Karl Fischer
Refractive Index	1.4320–1.4360 (20°C)	Refractometry

2.3 Impurity Profile

Impurity	Limit
(S)-Enantiomer	≤2.0%
Dimerization Products	≤1.0%
Solvent Residues	≤0.5% (total)

3. Physicochemical Properties

3.1 Key Properties

Property	Value
Boiling Point	75–78°C (10 mmHg)
Density	1.072 g/cm³ (20°C)
Flash Point	73°C (closed cup)
Solubility	Miscible with common organic solvents

3.2 Spectroscopic Data

✓ IR (neat): 1725 cm⁻¹ (C=O stretch)
✓ ¹H NMR (CDCl₃): δ 9.65 (s, 1H, CHO)

4. Product Applications

4.1 Synthetic Uses

✓ Chiral Building Block: Key intermediate for:

(R)-Glyceraldehyde derivatives
Carbohydrate mimetics
✓ Pharmaceutical Intermediates:
Antiviral agents
β-Lactam antibiotics

4.2 Recommended Handling

Stabilization: Store under inert gas (N₂/Ar)
Reaction Conditions: Stable under basic/neutral conditions

5. Packaging & Storage

5.1 Packaging Options

Format	Volume
R&D Samples	1–100 g (amber glass bottles)
Bulk Quantities	1–25 kg (HDPE drums)

5.2 Storage Conditions

✓ Temperature: 2–8°C (long-term), ≤25°C (short-term)
✓ Light Protection: Amber glass required
✓ Shelf Life: 24 months (unopened, under N₂)

6. Safety & Handling

6.1 Hazard Classification

⚠ GHS Symbols: Flam. Liq. 3 | Skin Irrit. 2
✓ NFPA Rating: Health 2, Flammability 2, Instability 0

6.2 Safety Precautions

Ventilation: Use in fume hood
PPE: Gloves + splash goggles
Incompatibilities: Strong oxidizers

6.3 Emergency Measures

Eye Contact: Rinse 15 min with water
Spill Control: Absorb with inert material

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

Tell us your challenge. We’ll build the solution.

Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.