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Levomefolic acid (L-5-MTHF) is the metabolically active form of folate, essential for DNA synthesis, methylation reactions, and homocysteine regulation. Compared to synthetic folic acid, it offers:
✔ Higher bioavailability – Directly utilized by the body
✔ Better absorption – Especially in individuals with MTHFR mutations
✔ Stability in formulations – Suitable for oral and injectable preparations
| Parameter | Specification |
|---|---|
| IUPAC Name | (2S)-2-[[4-[(2-Amino-5-methyl-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
| Synonyms | L-Methylfolate; (6S)-5-Methyltetrahydrofolate; L-5-MTHF |
| CAS Number | 31690-09-2 |
| Molecular Formula | C₂₀H₂₅N₇O₆ |
| Molecular Weight | 459.46 g/mol |
| EC Number | 250-719-3 |
| Solubility | Soluble in water (>10 mg/mL at pH 7.0) |
| Test Parameter | Specification | Method |
|---|---|---|
| Appearance | Yellow to orange powder | Visual |
| Assay (HPLC) | ≥98.0% | USP <621> |
| Water Content | ≤5.0% | Karl Fischer |
| Optical Rotation | +14° to +18° (c=1 in 0.1M NaOH) | Polarimetry |
| Residual Solvents | Meets ICH Q3C | GC-HS |
| Heavy Metals | ≤10 ppm | ICP-MS |
| Related Substances | Total impurities ≤2.0% | HPLC-UV |
| Property | Value | Test Condition |
|---|---|---|
| Melting Point | Decomposes above 210°C | DSC |
| pKa Values | 3.1, 4.8, 10.2 | Potentiometric |
| LogP | -2.0 (predicted) | Computational |
| Hygroscopicity | Slightly hygroscopic | DVS analysis |
| Stability | Stable at pH 6–8; sensitive to light/oxidation | Accelerated studies |
✔ Depression & mental health (adjunct therapy in SSRIs)
✔ Prenatal supplements (reduces neural tube defect risk)
✔ Cardiovascular health (lowers homocysteine levels)
✔ Cancer therapy support (mitigates antifolate toxicity)
| Packaging Option | Description |
|---|---|
| 100 mg – 1 g | Amber glass vial, nitrogen-purged |
| 5 g – 100 g | Double HDPE bags, desiccated |
| Bulk quantities | Customizable (foil-lined drums) |
Storage Conditions:
Shelf Life: 36 months when stored properly
✔ Generally Recognized as Safe (GRAS) for food use
✔ EP/USP/JP compliant
✔ DMF filed (US: #xxxxx, EU: xxxx/xxx)
✔ GMP-certified manufacturing
✔ Custom synthesis & salt forms available (Ca/Mg/Zn)
✔ Regulatory support & stability data
✔ Fast global shipping from EU/US/Asia warehouses
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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.
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