5-Methyltetrahydrofolic acid CAS 134-35-0

Key Features

✔High-purity bioactive folate derivative
✔Critical coenzyme in methylation reactions
✔Essential for DNA synthesis and cell metabolism
✔Synthetic analog of the natural biologically active folate form
✔Suitable for pharmaceutical and nutraceutical applications

Batch-specific CoA available on request.

Product Description

5-Methyltetrahydrofolic acid (5-MTHF) is the biologically active form of folate, playing a crucial role in one-carbon metabolism, homocysteine regulation, and nucleotide synthesis. As the predominant circulating folate in plasma, it serves as a vital coenzyme in methylation processes required for neurotransmitter production, detoxification, and genomic stability.

1. Product Identification

Chemical Name: 5-Methyltetrahydrofolic acid
Synonyms: 5-MTHF, L-Methylfolate, Metafolin
CAS Number: 134-35-0
Molecular Formula: C20H25N7O6
Molecular Weight: 459.46 g/mol
Appearance: Yellow to orange crystalline powder
Purity: ≥98% (HPLC)

2. Quality Specifications

Parameter	Specification
Assay (HPLC)	≥98%
Loss on Drying	≤2.0%
Residual Solvents	Meets Ph. Eur./USP limits
Heavy Metals	≤10 ppm
Microbial Limits	Complies with USP/EP standards

3. Physicochemical Properties

Solubility: Soluble in alkaline aqueous solutions
Melting Point: Decomposes above 240°C
Storage Stability: Sensitive to light, oxygen, and temperature
Chiral Form: Naturally occurring L-isomer

4. Product Applications

Pharmaceuticals: Treatment of folate deficiency, cardiovascular health (homocysteine reduction), neuropsychiatric disorders
Nutraceuticals: Prenatal supplements, fortified foods, metabolic support formulations
Clinical Research: Studies on methylation disorders, depression, cognitive decline
Diagnostics: Biomarker analysis in nutritional studies

5. Packaging & Storage

Packaging Options: 1g, 5g, 10g, 25g (amber glass vials); custom bulk quantities
Storage Condition: Store at -20°C, protected from light under inert gas (argon/nitrogen)
Shelf Life: 24 months when stored properly

6. Safety & Handling

Hazard Statements: Not classified as hazardous under GHS
Precautionary Measures: Avoid inhalation, skin contact, and prolonged exposure to light/moisture
First Aid Measures: In case of eye/skin contact, rinse thoroughly with water
Disposal: Follow local regulations for chemical waste disposal

Product MOQ

We understand that your requirements vary across different stages, from R&D and pilot scale to commercial production. Therefore, we support both:

R&D Samples: We offer sample sizes from gram to kilogram scale to support your early-stage project evaluation.
Commercial Supply: We provide standard industrial packaging (e.g., 25kg drums, 200kg drums) and have a stable capacity for bulk supply.

For detailed information on the Minimum Order Quantity (MOQ) for a specific product or to discuss custom packaging solutions, please contact our sales team.

Our Customization Capabilities Include

We bridge the gap between your concept and a commercial-ready product. Our flexible manufacturing and expert R&D team empower us to deliver fully customized chemical solutions.

Custom Synthesis: We develop molecules from lab scale to industrial production.
Specification Adjustment: We modify purity, form, and other key parameters to fit your application.
Flexible Packaging: We provide custom packaging and labeling to streamline your supply chain.

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Large or Small Order

Sample and bulk orders are welcome.
Supplying from grams to tons. Inquire for pricing.
We treat every order with the same dedication, large or small.

Technical Downloads

Technical Data Sheet (TDS)
Safety Data Sheet (SDS)
Request Certificate of Analysis (CoA)
Request a Quote

Inquiry & Ordering Information

Submit Inquiry: Contact us with the Product/CAS No., Quantity, and Purity requirements.
Receive Quote: Our team will provide a formal quotation and lead time.
Place Order: Confirm by issuing an official Purchase Order (PO).

Questions? Contact Us anytime.

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Reischbio provides confidential custom synthesis services, structured for innovative companies requiring unique and proprietary molecules. Our expert chemists leverage state-of-the-art reaction technologies to tackle complex, multi-step synthesis projects, from milligrams to multi-kilogram scale. Governed by strict IP protection protocols, we function as a seamless extension of your R&D team. Our agile project management and transparent communication ensure projects are delivered on-time and on-spec. With our bespoke chemistry solutions, we empower you to overcome scientific challenges, secure critical IP, and accelerate your path to innovation.